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Gunanti .
Institut Pertanian Bogor
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Journal : Medical Journal of Indonesia

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The effects of colloids or crystalloids on acute respiratory distress syndrome in swine (Sus scrofa) models with severe sepsis: analysis on extravascular lung water, IL-8, and VCAM-1 Dewi, Rismala; Supriyatno, Bambang; Madjid, Amir S.; Gunanti, Gunanti; Lubis, Munar
Medical Journal of Indonesia Vol 25, No 1 (2016): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (462.563 KB) | DOI: 10.13181/mji.v25i1.1204

Abstract

Background: Acute respiratory distress syndrome (ARDS) is a fatal complication of severe sepsis. Due to its higher molecular weight, the use of colloids in fluid resuscitation may be associated with fewer cases of ARDS compared to crystalloids. Extravascular lung water (EVLW) elevation and levels of interleukin-8 (IL-8) and vascular cell adhesion molecule-1 (VCAM-1) have been studied as indicators playing a role in the pathogenesis of ARDS. The aim of the study was to determine the effects of colloid or crystalloid on the incidence of ARDS, elevation of EVLW, and levels of IL-8 and VCAM-1, in swine models with severe sepsis.Methods: This was a randomized trial conducted at the Laboratory of Experimental Surgery, School of Veterinary Medicine, IPB, using 22 healthy swine models with a body weight of 8 to 12 kg. Subjects were randomly allocated to receive either colloid or crystalloid fluid resuscitation. After administration of endotoxin, clinical signs of ARDS, EVLW, IL-8, and VCAM-1 were monitored during sepsis, severe sepsis, and one- and three hours after fluid resuscitation. Analysis of data using the Wilcoxon test , Kolmogorov-Smirnov test, Mann-Whitney test, unpaired t test.Results: Mild ARDS was more prevalent in the colloid group, while moderate ARDS was more frequent in the crystalloid group. EVLW elevation was lower in the colloid compared to the crystalloid group. There was no significant difference in IL-8 and VCAM-1 levels between the two groups.Conclusion: The use of colloids in fluid resuscitation does not decrease the probability of ARDS events compared to crystalloids. Compared to crystalloids, colloids are associated with a lower increase in EVLWI, but not with IL-8 or VCAM-1 levels.
Co-Authors . Erwin Afifa, Selma Afiqah Binti Abd Latif Agik Suprayogi Agus Hadi Santosa Wargadipura Ahmad Arif Amin Ainul Khadija Saleema Amir S. Madjid, Amir S. Angesti, Shavrillia Anita Rahmayanti Annisa Rofiqoh Syafikriatillah Annita Vury Nurjunitar Antonius H. Pudjiadi, Antonius H. Arni Fitri Bambang Pontjo Priosoeryanto Bambang Supriyatno Basrul Hanafi Beata LYL Ayu Budianto Panjaitan Carina Khairunnisa D Ardiansyah D U Rahmiati Damiana Rita Ekastuti DENI NOVIANA Devi Paramitha Dina Zuhdina Rahman Dwi Endrawati Dwi Gustiono Dwi Utari Rahmiati E Fitriana Ega Iftahul Rizky Ekowati Handharyani Elok Budi Retnani Erwin Erwin Erwin Erwin Erwin Erwin Eva Harlina Fadhilah Nur Annisa Galih Satria Kusumanto Harits Abdullah Munir Hastjarjo Fleuryantari Helny Rosita Supriadi Helny Rosita Supriadi Heryudianto Vibowo Himah Nuradilah I Gusti Agung Ngurah Arphan Eka Putra I Gusti Ngurah Sudisma Intan Khoirunnisa Irda Khaeriyah Irza Sukmana Jessica Anggun Safitri Kholis Afidatunnisa Ki Agus Dahlan Kiagus Dahlan Kiagus Dahlan Kiagus Dahlan Laras Weningtyas Lina Noviyanti Sutardi Liza Oktafani M. Fakhrul Ulum Martapuri Rani Wijaya Masaji Washio Melpa Susanti Purba Melpa Susanti Purba Mokhamad Fakhrul Ulum Mokhamad Fakhrul Ulum Muhammad Abhi Purnomosidi Muhammad Fajrul Falah Munar Lubis, Munar Nabila Latifa Hafizsha Nadya Amanda Putri Najma Hayati Ni Rai Fertilini Hanira Jelantik Nindya Dwi Utami Nur Fitri Utami Nuzula Ramadian Peter Ian Limas R. Harry Soehartono Rachmi Ridho Raden Roro Soesatyoratih Rahul Ajie Saksena Ramadian, Nuzula Ravi, Sugganya Riana Nurul Maulani Riki Siswandi Riski Rostantinata Rismala Dewi Sandriya, Ardi Selma Afifa Selma Laily Nur Afifa Selma Laily Nur Afifah Septi Nurcholida Sari Shavrillia Angesti Shavrillia Inovanny Angesti Shayrilia Ivanovanny Angesti Sitaria Siallagan Siti Zaenab Srihadi Agungpriyono Sugganya Ravi Sus Derthi Widhyari Sus Derthi Widyari TATI NURHAYATI Tri Isyani Tungga Dewi Tytha Nadhifa Winarto Viyata Pratiwi Risky Yuliani Suparmin Zultinur Muttaqin